Welcome!

Agile Computing Authors: Elizabeth White, Liz McMillan, Stackify Blog, ManageEngine IT Matters, Carmen Gonzalez

News Feed Item

Study Shows that RapidArc® Radiosurgery Substantially More Efficient and Comparable in Quality to Gamma Knife® in the Treatment of Multiple Brain Metastases

Article in "Neurosurgery" describes how RapidArc Radiosurgery treatments can be specially optimized to treat multiple brain metastases at the same time

PALO ALTO, Calif., July 30, 2014 /PRNewswire/ -- RapidArc® Radiosurgery can be used to deliver treatments for multiple brain metastases that are substantially less time consuming and comparable in quality to Gamma Knife® (GK) treatments, according to a new research study recently posted online and slated for publication in the October issue of the journal Neurosurgery.1   

The research team found that the RapidArc Radiosurgery treatment plans for treating multiple tumors in a single fraction are comparable to Gamma Knife plans in terms of how precisely they can conform high doses to match the shape of the targeted tumors, as well as the extent to which RapidArc plans can minimize exposure of normal brain tissue outside the treatment area.

For their paper entitled Comparison of Plan Quality and Delivery Time between Volumetric Arc Therapy (RapidArc) and Gamma Knife Radiosurgery for Multiple Cranial Metastases, a clinical team at the University of Alabama, Birmingham (UAB) took 28 previously treated GK cases involving a total of 112 lesions and re-planned them using single fraction RapidArc Radiosurgery.  They used a special approach to RapidArc planning that calls for the beam to be delivered using non-coplanar arcs or rotations of the treatment machine around the patient, to maximize the number of treatment angles and enhance precision.  In addition, the UAB approach incorporates key optimization criteria that minimize the amount of low dose "spill" reaching normal brain tissues during treatment. 

"These findings show that it is possible to deliver radiosurgery to multiple brain metastases with precision comparable to a Gamma Knife treatment, but with far greater efficiency," said researcher Evan Thomas, PhD, primary author of the paper. 

"The authors conclude that the RapidArc plans yield 'clinically equivalent conformity.'  And the RapidArc treatments are substantially faster to deliver, making them more time efficient and potentially less taxing for patients," said Calvin Huntzinger, senior director of marketing for Varian's Surgical Sciences group. 

The UAB approach to RapidArc Radiosurgery planning for multiple metastases, which was previously described in an earlier paper published in 20122, makes use of key features that are built into Varian's Edge™ and TrueBeam™ STx platforms for image-guided radiosurgery, including Varian's HD120 high-definition multileaf collimator for ultra-fine beam shaping; the High Intensity Mode for delivering high doses quickly; and jaw tracking for extra shielding of normal tissues

RapidArc Radiosurgery treatments are faster than Gamma Knife treatments for a variety of reasons, including a dose delivery rate that is at least six times faster as well as the ability to treat multiple metastases simultaneously, rather than sequentially.  RapidArc Radiosurgery treatments at UAB are completed using frameless immobilization, without affixing the patient's skull to an immobilization frame as required for most Gamma Knife treatments.

"As we point out in our paper, brain metastases impact some 170,000 cancer patients in the US each year, and over 70 percent of those cases involve multiple metastases," said John Fiveash, MD, professor and vice chairman for academic programs at UAB, and senior author of the study.  "Using Varian's latest medical linear accelerators and RapidArc technology for volumetric modulated arc therapy (VMAT), we can devise treatments that offer the same level of conformity as Gamma Knife technology.  It's important to note that a RapidArc Radiosurgery treatment for multiple metastases can be completed in 22 minutes or less.*  A comparable Gamma Knife treatment might take between one and five hours, depending on the number of metastases involved."

One limitation of the study was that the Gamma Knife® Perfexion™, which claims performance improvements over previous models, was unavailable for the comparison.  In this study of mostly-spherical cranial metastasis, the authors did not expect the use of their Model 4C beam data to have a meaningful impact on the results of their dosimetric comparison.  Also, the authors report that improvements in treatment efficiency previously published for the Perfexion are modest when compared to the results reported in this study.

*Individual results will vary.  Refers to the time that the patient is in the treatment room.

About Varian Medical Systems                                                                                             
Varian Medical Systems, Inc. (NYSE: VAR), of Palo Alto, California, is the world's leading manufacturer of medical devices and software for treating cancer and other medical conditions with radiotherapy, radiosurgery, and brachytherapy. The company supplies informatics software for managing comprehensive cancer clinics, radiotherapy centers and medical oncology practices. Varian is a premier supplier of tubes, digital detectors, and image processing software and workstations for X-ray imaging in medical, scientific, and industrial applications and also supplies high-energy X-ray devices for cargo screening and non-destructive testing applications.  Varian Medical Systems employs approximately 6,500 people who are located at manufacturing sites in North America, Europe, and China and approximately 70 sales and support offices around the world. For more information, visit http://www.varian.com or follow us on Twitter.

Disclaimer:
The paper referenced here, accepted for publication in the journal Neurosurgery, represents a single center result and needs to be confirmed with results from other centers using the same or similar techniques.  As such this is a limited re-planning study comparing the quality of treatment plans; it does not prove clinical or treatment equivalence.  Varian's devices that deliver RapidArc Radiosurgery treatments, including the TrueBeam™ machine, have been cleared by the U.S. Food and Drug Administration (FDA) for treating lesions, tumors, and conditions anywhere in the body when radiation treatment is indicated.  

Disclosure:
Study co-authors, Drs. Fiveash, Popple, and Thomas have received honoraria from and/or served as consultants for Varian Medical Systems with regard to the UAB experience in treating patients with the TrueBeam STx. The other authors have no personal, financial, or institutional interest in any of the devices described in this article.

Important Safety Information
Radiosurgery may cause side effects that can vary depending on the part of the body being treated. The most frequent ones are typically temporary and may include, but are not limited to, fatigue, nausea, skin irritation, and hair loss. Treatment sessions may vary in complexity and time. Radiosurgery is not appropriate for all brain tumors. Cancer patients should discuss the potential for side effects and their severity as well as the benefits of radiosurgery with their doctors to determine if radiosurgery treatments are right for them.

1 Thomas EM et al.  Comparison of Plan Quality and Delivery Time between Volumetric Arc Therapy (RapidArc) and Gamma Knife Radiosurgery for Multiple Cranial MetastasesNeurosurgery  2014 May 27. [Epub ahead of print].
2 Clark GM, et al.  Plan quality and treatment planning technique for single isocenter cranial radiosurgery with volumetric modulated arc therapyPract_Radiat_Oncol 2012,2(4):306-313.

FOR INFORMATION CONTACT:

Meryl Ginsberg, 650-424-6444
[email protected]

SOURCE Varian Medical Systems, Inc.

More Stories By PR Newswire

Copyright © 2007 PR Newswire. All rights reserved. Republication or redistribution of PRNewswire content is expressly prohibited without the prior written consent of PRNewswire. PRNewswire shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

@ThingsExpo Stories
SYS-CON Events announced today that Ocean9will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Ocean9 provides cloud services for Backup, Disaster Recovery (DRaaS) and instant Innovation, and redefines enterprise infrastructure with its cloud native subscription offerings for mission critical SAP workloads.
SYS-CON Events announced today that Carbonite will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Carbonite protects your entire IT footprint with the right level of protection for each workload, ensuring lower costs and dependable solutions with DoubleTake and Evault.
SYS-CON Events announced today that Infranics will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Since 2000, Infranics has developed SysMaster Suite, which is required for the stable and efficient management of ICT infrastructure. The ICT management solution developed and provided by Infranics continues to add intelligence to the ICT infrastructure through the IMC (Infra Management Cycle) based on mathemat...
SYS-CON Events announced today that Cloudistics, an on-premises cloud computing company, has been named “Bronze Sponsor” of SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Cloudistics delivers a complete public cloud experience with composable on-premises infrastructures to medium and large enterprises. Its software-defined technology natively converges network, storage, compute, virtualization, and management into a ...
SYS-CON Events announced today that HTBase will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. HTBase (Gartner 2016 Cool Vendor) delivers a Composable IT infrastructure solution architected for agility and increased efficiency. It turns compute, storage, and fabric into fluid pools of resources that are easily composed and re-composed to meet each application’s needs. With HTBase, companies can quickly prov...
Internet of @ThingsExpo, taking place October 31 - November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with the 21st International Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. @ThingsExpo Silicon Valley Call for Papers is now open.
SYS-CON Events announced today that Systena America will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Systena Group has been in business for various software development and verification in Japan, US, ASEAN, and China by utilizing the knowledge we gained from all types of device development for various industries including smartphones (Android/iOS), wireless communication, security technology and IoT serv...
New competitors, disruptive technologies, and growing expectations are pushing every business to both adopt and deliver new digital services. This ‘Digital Transformation’ demands rapid delivery and continuous iteration of new competitive services via multiple channels, which in turn demands new service delivery techniques – including DevOps. In this power panel at @DevOpsSummit 20th Cloud Expo, moderated by DevOps Conference Co-Chair Andi Mann, panelists will examine how DevOps helps to meet th...
We build IoT infrastructure products - when you have to integrate different devices, different systems and cloud you have to build an application to do that but we eliminate the need to build an application. Our products can integrate any device, any system, any cloud regardless of protocol," explained Peter Jung, Chief Product Officer at Pulzze Systems, in this SYS-CON.tv interview at @ThingsExpo, held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA
Multiple data types are pouring into IoT deployments. Data is coming in small packages as well as enormous files and data streams of many sizes. Widespread use of mobile devices adds to the total. In this power panel at @ThingsExpo, moderated by Conference Chair Roger Strukhoff, panelists will look at the tools and environments that are being put to use in IoT deployments, as well as the team skills a modern enterprise IT shop needs to keep things running, get a handle on all this data, and deli...
SYS-CON Events announced today that Hitachi Data Systems, a wholly owned subsidiary of Hitachi LTD., will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City. Hitachi Data Systems (HDS) will be featuring the Hitachi Content Platform (HCP) portfolio. This is the industry’s only offering that allows organizations to bring together object storage, file sync and share, cloud storage gateways, and sophisticated search and...
SYS-CON Events announced today that SoftLayer, an IBM Company, has been named “Gold Sponsor” of SYS-CON's 18th Cloud Expo, which will take place on June 7-9, 2016, at the Javits Center in New York, New York. SoftLayer, an IBM Company, provides cloud infrastructure as a service from a growing number of data centers and network points of presence around the world. SoftLayer’s customers range from Web startups to global enterprises.
SYS-CON Events announced today that T-Mobile will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. As America's Un-carrier, T-Mobile US, Inc., is redefining the way consumers and businesses buy wireless services through leading product and service innovation. The Company's advanced nationwide 4G LTE network delivers outstanding wireless experiences to 67.4 million customers who are unwilling to compromise on ...
The 21st International Cloud Expo has announced that its Call for Papers is open. Cloud Expo, to be held October 31 - November 2, 2017, at the Santa Clara Convention Center in Santa Clara, CA, brings together Cloud Computing, Big Data, Internet of Things, DevOps, Digital Transformation, Machine Learning and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding busin...
SYS-CON Events announced today that Loom Systems will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Founded in 2015, Loom Systems delivers an advanced AI solution to predict and prevent problems in the digital business. Loom stands alone in the industry as an AI analysis platform requiring no prior math knowledge from operators, leveraging the existing staff to succeed in the digital era. With offices in S...
SYS-CON Events announced today that Linux Academy, the foremost online Linux and cloud training platform and community, will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Linux Academy was founded on the belief that providing high-quality, in-depth training should be available at an affordable price. Industry leaders in quality training, provided services, and student certification passes, its goal is to c...
Adopting the right Digital Transformation strategy for your enterprise is crucial to keep up with rapid growth, customers' demands, and technological disruptions while remaining ahead of your market competition. Digital Transformation is no longer an option, it’s a requirement. Are you ready for tomorrow’s challenges? In his session at 20th Cloud Expo, William Morrish, VP of Commercial Operations at Interoute, will discuss these key takeaways.
SYS-CON Events announced today that Fusion, a leading provider of cloud services, will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Fusion, a leading provider of integrated cloud solutions to small, medium and large businesses, is the industry’s single source for the cloud. Fusion’s advanced, proprietary cloud service platform enables the integration of leading edge solutions in the cloud, including cloud...
SYS-CON Events announced today that Peak 10, Inc., a national IT infrastructure and cloud services provider, will exhibit at SYS-CON's 20th International Cloud Expo®, which will take place on June 6-8, 2017, at the Javits Center in New York City, NY. Peak 10 provides reliable, tailored data center and network services, cloud and managed services. Its solutions are designed to scale and adapt to customers’ changing business needs, enabling them to lower costs, improve performance and focus intern...
Existing Big Data solutions are mainly focused on the discovery and analysis of data. The solutions are scalable and highly available but tedious when swapping in and swapping out occurs in disarray and thrashing takes place. The resolution for thrashing through machine learning algorithms and support nomenclature is through simple techniques. Organizations that have been collecting large customer data are increasingly seeing the need to use the data for swapping in and out and thrashing occurs ...