|By PR Newswire||
|July 30, 2014 08:00 AM EDT||
PALO ALTO, Calif., July 30, 2014 /PRNewswire/ -- RapidArc® Radiosurgery can be used to deliver treatments for multiple brain metastases that are substantially less time consuming and comparable in quality to Gamma Knife® (GK) treatments, according to a new research study recently posted online and slated for publication in the October issue of the journal Neurosurgery.1
The research team found that the RapidArc Radiosurgery treatment plans for treating multiple tumors in a single fraction are comparable to Gamma Knife plans in terms of how precisely they can conform high doses to match the shape of the targeted tumors, as well as the extent to which RapidArc plans can minimize exposure of normal brain tissue outside the treatment area.
For their paper entitled Comparison of Plan Quality and Delivery Time between Volumetric Arc Therapy (RapidArc) and Gamma Knife Radiosurgery for Multiple Cranial Metastases, a clinical team at the University of Alabama, Birmingham (UAB) took 28 previously treated GK cases involving a total of 112 lesions and re-planned them using single fraction RapidArc Radiosurgery. They used a special approach to RapidArc planning that calls for the beam to be delivered using non-coplanar arcs or rotations of the treatment machine around the patient, to maximize the number of treatment angles and enhance precision. In addition, the UAB approach incorporates key optimization criteria that minimize the amount of low dose "spill" reaching normal brain tissues during treatment.
"These findings show that it is possible to deliver radiosurgery to multiple brain metastases with precision comparable to a Gamma Knife treatment, but with far greater efficiency," said researcher Evan Thomas, PhD, primary author of the paper.
"The authors conclude that the RapidArc plans yield 'clinically equivalent conformity.' And the RapidArc treatments are substantially faster to deliver, making them more time efficient and potentially less taxing for patients," said Calvin Huntzinger, senior director of marketing for Varian's Surgical Sciences group.
The UAB approach to RapidArc Radiosurgery planning for multiple metastases, which was previously described in an earlier paper published in 20122, makes use of key features that are built into Varian's Edge™ and TrueBeam™ STx platforms for image-guided radiosurgery, including Varian's HD120 high-definition multileaf collimator for ultra-fine beam shaping; the High Intensity Mode for delivering high doses quickly; and jaw tracking for extra shielding of normal tissues
RapidArc Radiosurgery treatments are faster than Gamma Knife treatments for a variety of reasons, including a dose delivery rate that is at least six times faster as well as the ability to treat multiple metastases simultaneously, rather than sequentially. RapidArc Radiosurgery treatments at UAB are completed using frameless immobilization, without affixing the patient's skull to an immobilization frame as required for most Gamma Knife treatments.
"As we point out in our paper, brain metastases impact some 170,000 cancer patients in the US each year, and over 70 percent of those cases involve multiple metastases," said John Fiveash, MD, professor and vice chairman for academic programs at UAB, and senior author of the study. "Using Varian's latest medical linear accelerators and RapidArc technology for volumetric modulated arc therapy (VMAT), we can devise treatments that offer the same level of conformity as Gamma Knife technology. It's important to note that a RapidArc Radiosurgery treatment for multiple metastases can be completed in 22 minutes or less.* A comparable Gamma Knife treatment might take between one and five hours, depending on the number of metastases involved."
One limitation of the study was that the Gamma Knife® Perfexion™, which claims performance improvements over previous models, was unavailable for the comparison. In this study of mostly-spherical cranial metastasis, the authors did not expect the use of their Model 4C beam data to have a meaningful impact on the results of their dosimetric comparison. Also, the authors report that improvements in treatment efficiency previously published for the Perfexion are modest when compared to the results reported in this study.
*Individual results will vary. Refers to the time that the patient is in the treatment room.
About Varian Medical Systems
Varian Medical Systems, Inc. (NYSE: VAR), of Palo Alto, California, is the world's leading manufacturer of medical devices and software for treating cancer and other medical conditions with radiotherapy, radiosurgery, and brachytherapy. The company supplies informatics software for managing comprehensive cancer clinics, radiotherapy centers and medical oncology practices. Varian is a premier supplier of tubes, digital detectors, and image processing software and workstations for X-ray imaging in medical, scientific, and industrial applications and also supplies high-energy X-ray devices for cargo screening and non-destructive testing applications. Varian Medical Systems employs approximately 6,500 people who are located at manufacturing sites in North America, Europe, and China and approximately 70 sales and support offices around the world. For more information, visit http://www.varian.com or follow us on Twitter.
The paper referenced here, accepted for publication in the journal Neurosurgery, represents a single center result and needs to be confirmed with results from other centers using the same or similar techniques. As such this is a limited re-planning study comparing the quality of treatment plans; it does not prove clinical or treatment equivalence. Varian's devices that deliver RapidArc Radiosurgery treatments, including the TrueBeam™ machine, have been cleared by the U.S. Food and Drug Administration (FDA) for treating lesions, tumors, and conditions anywhere in the body when radiation treatment is indicated.
Study co-authors, Drs. Fiveash, Popple, and Thomas have received honoraria from and/or served as consultants for Varian Medical Systems with regard to the UAB experience in treating patients with the TrueBeam STx. The other authors have no personal, financial, or institutional interest in any of the devices described in this article.
Important Safety Information:
Radiosurgery may cause side effects that can vary depending on the part of the body being treated. The most frequent ones are typically temporary and may include, but are not limited to, fatigue, nausea, skin irritation, and hair loss. Treatment sessions may vary in complexity and time. Radiosurgery is not appropriate for all brain tumors. Cancer patients should discuss the potential for side effects and their severity as well as the benefits of radiosurgery with their doctors to determine if radiosurgery treatments are right for them.
1 Thomas EM et al. Comparison of Plan Quality and Delivery Time between Volumetric Arc Therapy (RapidArc) and Gamma Knife Radiosurgery for Multiple Cranial Metastases. Neurosurgery 2014 May 27. [Epub ahead of print].
2 Clark GM, et al. Plan quality and treatment planning technique for single isocenter cranial radiosurgery with volumetric modulated arc therapy. Pract_Radiat_Oncol 2012,2(4):306-313.
FOR INFORMATION CONTACT:
Meryl Ginsberg, 650-424-6444
SOURCE Varian Medical Systems, Inc.
Avnet, Inc. has announced that it ranked No. 4 on the InformationWeek Elite 100 – a list of the top business technology innovators in the U.S. Avnet was recognized for the development of an innovative cloud-based training system that serves as the foundation for Avnet Academy – the company’s education and training organization focused on technical training around top IT vendor technologies. The development of this system allowed Avnet to quickly expand its IT-related training capabilities around the world, while creating a new service that Avnet and its IT solution providers can offer to their...
May. 4, 2015 01:30 PM EDT Reads: 568
SYS-CON Events announced today that B2Cloud, a provider of enterprise resource planning software, will exhibit at SYS-CON's 16th International Cloud Expo®, which will take place on June 9-11, 2015, at the Javits Center in New York City, NY. B2cloud develops the software you need. They have the ideal tools to help you work with your clients. B2Cloud’s main solutions include AGIS – ERP, CLOHC, AGIS – Invoice, and IZUM
May. 4, 2015 12:00 PM EDT Reads: 4,411
The Internet of Things Maturity Model (IoTMM) is a qualitative method to gauge the growth and increasing impact of IoT capabilities in an IT environment from both a business and technology perspective. In his session at @ThingsExpo, Tony Shan will first scan the IoT landscape and investigate the major challenges and barriers. The key areas of consideration are identified to get started with IoT journey. He will then pinpoint the need of a tool for effective IoT adoption and implementation, which leads to IoTMM in which five maturity levels are defined: Advanced, Dynamic, Optimized, Primitive,...
May. 4, 2015 12:00 PM EDT Reads: 1,060
With major technology companies and startups seriously embracing IoT strategies, now is the perfect time to attend @ThingsExpo in Silicon Valley. Learn what is going on, contribute to the discussions, and ensure that your enterprise is as "IoT-Ready" as it can be! Internet of @ThingsExpo, taking place Nov 3-5, 2015, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with 17th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. The Internet of Things (IoT) is the most profound change in personal an...
May. 4, 2015 11:22 AM EDT Reads: 492
There is no doubt that Big Data is here and getting bigger every day. Building a Big Data infrastructure today is no easy task. There are an enormous number of choices for database engines and technologies. To make things even more challenging, requirements are getting more sophisticated, and the standard paradigm of supporting historical analytics queries is often just one facet of what is needed. As Big Data growth continues, organizations are demanding real-time access to data, allowing immediate and actionable interpretation of events as they happen. Another aspect concerns how to deliver ...
May. 4, 2015 11:00 AM EDT Reads: 5,700
Enterprise IoT is an exciting and chaotic space with a lot of potential to transform how the enterprise resources are managed. In his session at @ThingsExpo, Hari Srinivasan, Sr Product Manager at Cisco, will describe the challenges in enabling mass adoption of IoT, and share perspectives and insights on architectures/standards/protocols that are necessary to build a healthy ecosystem and lay the foundation to for a wide variety of exciting IoT use cases in the years to come.
May. 4, 2015 11:00 AM EDT Reads: 1,206
The world's leading Cloud event, Cloud Expo has launched Microservices Journal on the SYS-CON.com portal, featuring over 19,000 original articles, news stories, features, and blog entries. DevOps Journal is focused on this critical enterprise IT topic in the world of cloud computing. Microservices Journal offers top articles, news stories, and blog posts from the world's well-known experts and guarantees better exposure for its authors than any other publication. Follow new article posts on Twitter at @MicroservicesE
May. 4, 2015 11:00 AM EDT Reads: 2,863
Containers and microservices have become topics of intense interest throughout the cloud developer and enterprise IT communities. Accordingly, attendees at the upcoming 16th Cloud Expo at the Javits Center in New York June 9-11 will find fresh new content in a new track called PaaS | Containers & Microservices Containers are not being considered for the first time by the cloud community, but a current era of re-consideration has pushed them to the top of the cloud agenda. With the launch of Docker's initial release in March of 2013, interest was revved up several notches. Then late last...
May. 4, 2015 11:00 AM EDT Reads: 3,810
WebRTC defines no default signaling protocol, causing fragmentation between WebRTC silos. SIP and XMPP provide possibilities, but come with considerable complexity and are not designed for use in a web environment. In his session at @ThingsExpo, Matthew Hodgson, technical co-founder of the Matrix.org, discussed how Matrix is a new non-profit Open Source Project that defines both a new HTTP-based standard for VoIP & IM signaling and provides reference implementations.
May. 4, 2015 10:45 AM EDT Reads: 4,277
So I guess we’ve officially entered a new era of lean and mean. I say this with the announcement of Ubuntu Snappy Core, “designed for lightweight cloud container hosts running Docker and for smart devices,” according to Canonical. “Snappy Ubuntu Core is the smallest Ubuntu available, designed for security and efficiency in devices or on the cloud.” This first version of Snappy Ubuntu Core features secure app containment and Docker 1.6 (1.5 in main release), is available on public clouds, and for ARM and x86 devices on several IoT boards. It’s a Trend! This announcement comes just as...
May. 4, 2015 10:45 AM EDT Reads: 2,180
The security devil is always in the details of the attack: the ones you've endured, the ones you prepare yourself to fend off, and the ones that, you fear, will catch you completely unaware and defenseless. The Internet of Things (IoT) is nothing if not an endless proliferation of details. It's the vision of a world in which continuous Internet connectivity and addressability is embedded into a growing range of human artifacts, into the natural world, and even into our smartphones, appliances, and physical persons. In the IoT vision, every new "thing" - sensor, actuator, data source, data con...
May. 4, 2015 10:30 AM EDT Reads: 5,304
It's time to put the "Thing" back in IoT. Whether it’s drones, robots, self-driving cars, ... There are multiple incredible examples of the power of IoT nowadays that are shadowed by announcements of yet another twist on statistics, databases, .... Sorry, I meant, Big Data(TM), tiered storage(TM), complex systems(TM), smart nations(TM), .... In his session at WebRTC Summit, Dr Alex Gouaillard, CTO and Co-Founder of Temasys, will discuss the concrete, cool, examples of IoT already happening today, and how mixing all those different sources of visual and audio input can make your life happier ...
May. 4, 2015 10:04 AM EDT Reads: 472
The Internet of Things is not new. Historically, smart businesses have used its basic concept of leveraging data to drive better decision making and have capitalized on those insights to realize additional revenue opportunities. So, what has changed to make the Internet of Things one of the hottest topics in tech? In his session at @ThingsExpo, Chris Gray, Director, Embedded and Internet of Things, discussed the underlying factors that are driving the economics of intelligent systems. Discover how hardware commoditization, the ubiquitous nature of connectivity, and the emergence of Big Data a...
May. 4, 2015 10:00 AM EDT Reads: 5,475
SYS-CON Events announced today the IoT Bootcamp – Jumpstart Your IoT Strategy, being held June 9–10, 2015, in conjunction with 16th Cloud Expo and Internet of @ThingsExpo at the Javits Center in New York City. This is your chance to jumpstart your IoT strategy. Combined with real-world scenarios and use cases, the IoT Bootcamp is not just based on presentations but includes hands-on demos and walkthroughs. We will introduce you to a variety of Do-It-Yourself IoT platforms including Arduino, Raspberry Pi, BeagleBone, Spark and Intel Edison. You will also get an overview of cloud technologies s...
May. 4, 2015 10:00 AM EDT Reads: 3,880
SYS-CON Media announced today that @WebRTCSummit Blog, the largest WebRTC resource in the world, has been launched. @WebRTCSummit Blog offers top articles, news stories, and blog posts from the world's well-known experts and guarantees better exposure for its authors than any other publication. @WebRTCSummit Blog can be bookmarked ▸ Here @WebRTCSummit conference site can be bookmarked ▸ Here
May. 4, 2015 09:45 AM EDT Reads: 3,361
Scott Jenson leads a project called The Physical Web within the Chrome team at Google. Project members are working to take the scalability and openness of the web and use it to talk to the exponentially exploding range of smart devices. Nearly every company today working on the IoT comes up with the same basic solution: use my server and you'll be fine. But if we really believe there will be trillions of these devices, that just can't scale. We need a system that is open a scalable and by using the URL as a basic building block, we open this up and get the same resilience that the web enjoys.
May. 4, 2015 09:45 AM EDT Reads: 5,821
The WebRTC Summit 2015 New York, to be held June 9-11, 2015, at the Javits Center in New York, NY, announces that its Call for Papers is open. Topics include all aspects of improving IT delivery by eliminating waste through automated business models leveraging cloud technologies. WebRTC Summit is co-located with 16th International Cloud Expo, @ThingsExpo, Big Data Expo, and DevOps Summit.
May. 4, 2015 09:15 AM EDT Reads: 3,102
Chuck Piluso will present a study of cloud adoption trends and the power and flexibility of IBM Power and Pureflex cloud solutions. Speaker Bio: Prior to Data Storage Corporation (DSC), Mr. Piluso founded North American Telecommunication Corporation, a facilities-based Competitive Local Exchange Carrier licensed by the Public Service Commission in 10 states, serving as the company's chairman and president from 1997 to 2000. Between 1990 and 1997, Mr. Piluso served as chairman & founder of International Telecommunications Corporation, a facilities-based international carrier licensed by t...
May. 4, 2015 09:00 AM EDT Reads: 783
There are lots of challenges in IoT around secure, scalable and business friendly infrastructure for enterprises. For large corporations, IoT implementations are one of the top priorities of the decade. All industries are seeing a competitive need to sustain by investing in IoT initiatives. The value addition comes from improved customer service, innovative product and additional revenue streams. The data from these IP-connected devices can be leveraged for a variety of business applications as well as responsive action controls. The various architectural building blocks of an IoT ...
May. 4, 2015 09:00 AM EDT Reads: 1,117
Recent technology advances in miniaturization has positioned the wearables as the pinnacle of technology convergence with the human body. We inquire if wearables are mere standard miniaturized devices extended with the connectivity and present our views on considerations like design, applications, performance, efficiency, interoperability, usage scenarios, human device interaction and consequent trade-offs enabling wearables to impart optimal value.
May. 4, 2015 08:00 AM EDT Reads: 1,737