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Agile Computing Authors: Elizabeth White, Liz McMillan, Karyn Jeffery, Jeev Trika, Scott Allen

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Appistry Teams with Personal Genome Diagnostics to Offer CancerSelect™ Test through Appistry CloudDx™

Appistry, Inc., a leading provider of tools, software, and services that bring the power of genomics to next-generation medicine, today announced an agreement with Personal Genome Diagnostics (PGDx) to include the company’s CancerSelect™ panel in Appistry’s recently released Appistry CloudDx™ genomics testing service. PGDx, a provider of CLIA-compliant genomics services to oncology researchers, drug developers, clinicians, and patients, is among the first organizations to offer lab-developed tests (LDTs) through Appistry’s cloud-based service that makes LDTs from leading diagnostic test providers available to physicians across the United States. Appistry CloudDx was launched at the 2014 ASCO Annual Meeting held in Chicago May 30–June 3, 2014.

CancerSelect targets 120 genes of clinical and biological importance to cancer, providing information that can help physicians individualize treatment to a patient’s cancer. The CancerSelect panel is sequenced in PGDx’s CLIA-certified laboratory, and the analysis is conducted using PGDx’s proprietary algorithms that provide extremely high coverage, copy number analyses for 63 genes, and translocation analysis for 17 genes.

Appistry will collaborate with PGDx to deliver a report to participating physicians containing a pathological evaluation of the tumor sample; tumor-specific mutations (alterations and substitutions, amplifications, and translocations); a description of mutated genes and pathways along with biologic and clinical implications; full statistics; and therapeutic, predictive, and prognostic information and references, as well as referral information for ongoing clinical trials that might be relevant based on the analysis results.

Appistry CloudDx streamlines and simplifies the workflow associated with genomics-based testing, which has been limited in its impact, partly because it requires organizations to amass infrastructure and expertise to deliver relevant results that are usable by physicians. Appistry CloudDx provides a single web dashboard for ordering and tracking the progress of tests and orchestrates the data flow between test providers such as PGDx and requesting physicians and hospitals, thereby ensuring that data and physical samples are transferred and securely managed in accordance with HIPAA and CLIA guidelines.

“PGDx is committed to applying the latest genomics technology to deliver comprehensive, reliable, unbiased analyses of cancer-related mutations,” said Antony Newton, chief commercial officer at PGDx. “Making CancerSelect available through Appistry CloudDx will extend our reach, enabling our panel to be utilized more broadly by community physicians looking to provide the best diagnostic and treatment options to their patients.”

“Appistry’s aim is to enable physicians everywhere to implement genomics-based tests, regardless of geography, institutional size, or medical system affiliation,” said Kevin Haar, chief executive officer of Appistry. “We are excited that PGDx’s CancerSelect test will be available as the first offering in Appistry CloudDx, as it is a great example of the type of high-quality, leading-edge medicine that physicians need in order to deliver genomically enhanced medicine to their patients.”

Appistry will be demonstrating CloudDx at Booth #16152 at the 2014 ASCO Annual Meeting in Chicago May 30–June 3, 2014. More information about Appistry CloudDx can be found at appistry.com/gem. More information about CancerSelect can be found at personalgenome.com/cancerselect.

About Appistry

Appistry, Inc., brings the power of genomics to next-generation medicine by making genomics data easier for researchers and clinicians to act on. Appistry CloudDx provides cost-effective access to established, laboratory developed tests so that clinically relevant genomics-based information can be usable by any physician, anywhere. Appistry also empowers researchers by providing world-class bioinformatics tools, cloud services, and software that streamline the analysis of next-generation sequencing data and provide easy scale for moving research-developed pipelines into production. Learn more by connecting with Appistry on Facebook, Twitter and LinkedIn.

About Personal Genome Diagnostics

Personal Genome Diagnostics (PGDx) provides advanced cancer genome analyses to oncology researchers, drug developers, clinicians and patients. The company uses advanced genomic methods and its deep expertise in cancer biology to identify and characterize the unique genomic alterations in tumors. PGDx’s proprietary methods for genome sequencing and analysis are complemented by its extensive experience in cancer genomics and clinical oncology. The founders of PGDx, Luis Diaz, MD, and Victor Velculescu, MD, PhD, are internationally recognized leaders in cancer genomics at Johns Hopkins University who have extensive experience in the practical application of advanced genomic technologies to drug development and clinical practice. PGDx’s CLIA-certified facility provides personalized cancer genome analyses to patients and their physicians. For more information, visit www.personalgenome.com.

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